⁤⁤Researchers at McMaster University recently discovered a signaling pathway — known as PTP4A-ROBO1 — that glioblastoma (GBM) cells exploit to invade the brain. ⁤⁤Their study highlights a novel CAR T cell therapy targeting this pathway, showing promising results in preclinical models. ⁤⁤In experiments ROBO1 CAR T cells successfully eradicated tumors in 50-100% of mice with brain cancer, including GBM, lung-to-brain metastasis, and medulloblastoma. ⁤⁤The therapy also doubled survival time in treated animals. ⁤⁤The team suggests this approach could revolutionize treatment for GBM and other aggressive brain cancers, which have seen little advancement in care over the past two decades. ⁤⁤Their findings offer hope for developing new clinical strategies to target these invasive malignancies, potentially leading to more effective treatments that could prevent tumor recurrence and extend patient survival.

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[Source: GenEngNews, August 1st 2024.]