Experts provide insight into high-throughput cognition testing of individual rodents within their social environment, discussing how this supports increased animal welfare and decreased data variability and workload for the researcher.

During this exclusive webinar sponsored by, TSE Systems, Drs. Ewelina Knapska, David Wolfer, and Holger Russig review automated home-cage behavioral phenotyping using the IntelliCage system and discuss several research applications including the study of hippocampus-dependent spatial learning tasks, measuring motor impulsivity, studying the role of MMP-9 in the central amygdala in learning of appetitively and aversively motivated behaviors, and assessing cognitive rigidity in a mouse models of autism.

After establishing basic concepts, presenters demonstrate how freely programmable behavioral tasks can be controlled and how to link them to established paradigms performed in biomedical and basic behavioral, neurobiological, psychiatric, pharmacological and genetic research. The implications for understanding therapeutic strategies is also discussed.

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#ExpertAnswers: David Wolfer, Ewelina Knapska, and Holger Russig on Rodent Behaviour

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Presenters

David P. Wolfer, ;MD

David P. Wolfer, MD

Associate Professor of Anatomy
Institute of Anatomy
University of Zurich

Ewelina Knapska, ;PhD

Ewelina Knapska, PhD

Laboratory of Emotions Neurobiology
Nencki Institute of Experimental Biology

Holger Russig, ;PhD

Holger Russig, PhD

Scientific Officer
TSE Systems Inc.

Production Partner

TSE Systems

TSE Systems is the leading global partner in providing advanced solutions for in vivo metabolic research. We assure researchers to achieve accurate, high-resolution data for studying metabolism, energy expenditure, and physiological changes in rodent models. With high-speed indirect calorimetry, we constantly investigate energy expenditure and monitor in parallel with other modules of the PhenoMaster factors which have an impact on EE such as food/liquid intake, body weight, and temperature or locomotor activity. In collaboration with scientists investigating the microbiome's role, we recently developed various additional features. PhenoMaster placed in an Isolator and equipped with additional H2 sensors allows study of germ-free animals or the activity of a defined microbiome. Stable isotope tracing using CO12/13 sensors has been used to identify metabolic changes induced by cancer.

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