Dr. Karyn Esser presents the critical role of skeletal muscle circadian clocks in maintaining muscle strength, metabolic health, and systemic adaptations to endurance exercise.
Circadian clocks are ~24hr molecular timers that exist in virtually all cells in the body, and they function to support cell, tissue and systemic homeostasis. This session will cover the preclinical and clinical data supporting the role for circadian clocks in skeletal muscle homeostasis through management of pathways important for maintenance of muscle strength and metabolic flexibility. In addition, this session will cover studies demonstrating the important role for skeletal muscle clocks as a key modulator of known healthy adaptations to endurance exercise. Lastly, the discussion will integrate changes in muscle clocks, muscle health as important contributors to systemic, non-muscle tissue health.
Key Topics Include:
- Define the molecular organization and logic of circadian clocks
- Delineate mechanisms by which circadian clocks regulate skeletal muscle homeostasis (strength and metabolism)
- Dissect the interaction between skeletal muscle clocks and endurance exercise adaptations
- Interpret circadian modulation as a mechanistic variable in experimental and translational study design
Presenters
Professor and Chair
Physiology and Aging
University of Florida
Dr. Karyn Esser is Professor and Chair of Physiology and Aging at the University of Florida. Her lab helped establish circadian clocks in skeletal muscle and their role in maintaining strength and metabolic flexibility. Her work examines muscle clocks as components of exercise responses, aging and chronic diseases.
Production Partner
Aurora Scientific, Inc.
Aurora Scientific supports the scientific community in its goal of research and discovery by providing precision instrumentation of the highest quality design, construction and functionality for Muscle Physiology, Material Science and Neuroscience applications.
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