The Hidden Variable in Your Intestinal Organoids: Enhancing Differentiation for a More Predictive Model

Are you confident that your intestinal organoid models contain the right cell types to generate predictive, reproducible, and translatable results?

Join Dr. Martin Stahl in this webinar as he explores why understanding the cellular composition of your organoids matters–whether they are fully differentiated, missing rare-but-critical cell populations, or lacking key intestinal cell types. Using insights from recent research, he’ll demonstrate how differentiated cell states can alter drug response and toxicity readouts, potentially affecting the conclusions you draw from your studies.

Discover how IntestiCult™ Plus, a new, next-generation intestinal organoid growth medium, is designed to improve the balance of cell types within intestinal organoids. With the ability to support both expansion and differentiation within a single medium, IntestiCult™ Plus enables researchers to develop intestinal organoids that more accurately model the human intestinal epithelium, including improved representation of enteroendocrine cells, paneth cells, tuft cells, mature enterocytes, and other key cell populations.

Key Topics Include:

Learn how experimental outcomes are impacted by the proliferative versus differentiated state of your intestinal organoids.
Understand the limitations of current intestinal organoid culture methods, including the trade-offs between expansion and differentiation, and how these factors influence the physiological relevance of your model.
Discover how a next-generation intestinal organoid culture medium enables balanced expansion and differentiation, helping you generate organoid models that more accurately represent the human intestinal epithelium.
Gain practical insights into evaluating and refining your intestinal organoid models to ensure they align with your specific research questions and experimental needs.

Resources

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Presenters

Martin Stahl, PhD

Senior Scientist
Research and Development
STEMCELL Technologies

Dr. Martin Stahl is a Senior Scientist with the Intestinal Team at STEMCELL Technologies. Martin received a PhD in Microbiology at the University of Ottawa and conducted his postdoctoral research at the University of British Columbia and the BC Children’s Hospital Research Institute, where he studied infection and immunity in the gut.

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Production Partner

STEMCELL Technologies Inc.

STEMCELL Technologies provides specialized cell culture media, cell isolation products, and reagents for your cell therapy and drug discovery research. Our ethically sourced human primary cell portfolio includes products from peripheral blood, cord blood, and bone marrow.

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