#ExpertAnswers: Marrit Putker, Saskia De Man, and Pirouz Daftarian on T Cell-Directed Immunotherapy
Marrit Putker, Saskia De Man, and Pirouz Daftarian from Crown Bioscience discuss T cell-directed immunotherapy on the cancer-immunity cycle, including mechanisms and targets capable of modulating and enhancing T cell activity and the application of methods and models including organoids and high content imaging.
#ExpertAnswers: Dudley Lamming on the Influence of Sex and Genetic Background on Diet
Dudley Lamming, PhD, explains that “We Are More Than What We Eat”; Sex and Genetic background are important factors in observing responses to diet in mice.
#ExpertAnswers: Phil Griffiths on Telemetry Studies
Phil Griffiths draws from his experience as a telemetry user to discuss some important considerations for designing telemetry studies.
#ExpertAnswers: Cole McLarty, Nick Glover, and Tim Hacker on Pressure-Volume Loops
Cole McLarty, Nick Glover and Dr. Timothy Hacker focus on Pressure-Volume Loop collection and data analysis for cardiovascular research.
#ExpertAnswers: George Portugal on Microelectrode Array Technology
George Portugal discusses microelectrode array (MEA) technology used for cardiac research and some best practices for integrating this technique into your research protocols.
#ExpertAnswers: Dennis Turner on the Metabolics of Dementia
Dennis Turner delves into dementia syndrome, the metabolic changes that occur, and the importance of proper physiological monitoring of animal models.
#ExpertAnswers: Rajendra Kumari and Gera Goverse on the Cancer Immunity Cycle
Rajendra Kumari and Gera Goverse provide an overview of the cancer immunity cycle and present several methods, techniques, and model systems for immuno-oncology research.
#ExpertAnswers: Oscar Perez Leal and Jon Weidanz on Gene Editing
Oscar Perez Leal and Jon Weidanz discuss the basis of the FAST-HDR gene-editing system to create custom cell lines, and present case studies highlighting several applications.
#ExpertAnswers: Amy Sheng on Antibody Screening and Discovery
Amy Sheng provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody discovery.
#ExpertAnswers: Ejvind Mørtz on Protein Analysis
Ejvind Mørtz discusses the benefits and applications of mass spectrometry (MS)-based host cell protein (HCP) analysis and why HCP ELISAs are insufficient for documenting product-related impurities.
#ExpertAnswers: Andrew Taylor on Drug Metabolism
Andrew Taylor provides an overview of processes by which drugs are metabolized and talks about the importance of drug metabolism and drug-drug interaction studies.
#ExpertAnswers: Giacomo Rossitto on Heart Failure and Lymphatic Dysfunction
Giacomo Rossitto answers questions from a recent webinar where he shares his research on heart failure and the related lymphatic dysfunction in patients.
#ExpertAnswers: Jonathan Brestoff on Energy Expenditure
Jonathan Brestoff explains how energy expenditure can be better described thanks to a new bioinformatic algorithm known as Clambake.
#ExpertAnswers: Michael Sturek on Macrovascular Atherosclerosis and Microvascular Dysfunction
Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underlie ischemic events and the need for appropriate animal models for optimal translation.
#ExpertAnswers: David Barefield on Atrial Dysfunction
David Barefield discusses his work investigating the role of the Myosin binding protein H-like (MyBP-HL) protein in atrial dysfunction.
#ExpertAnswers: Eduardo Marbán on Regenerative Cardiovascular Medicine
Eduardo Marbán dives into the complexities of regenerative cardiovascular medicine and the future directions for cell therapies.
#ExpertAnswers: Jason Rogers and Eliala Salvadori on Infant Emotional Communication
Jason Rogers and Eliala Salvadori answer questions from a recent webinar that discussed research involving infant emotional communication patterns and coded behaviors.
#ExpertAnswers: Bradley Palmer on Measuring Cardiac Tissue
Bradley Palmer answers questions from a recent webinar where he highlighted and demonstrated the challenging preparation of cardiac tissue slices and measurement of force and calcium.
#ExpertAnswers: Adrián Rodríguez-Contreras and Barbara Lind on Neurovascular Coupling
Adrián Rodríguez-Contreras and Barbara Lind discuss their work on neurovascular coupling in awake head-fixed and anesthetized mice, with a focus on the effects of anesthetics.
#ExpertAnswers: Ana Briones on Targeting Inflammation and Vascular Damage in Hypertension
Ana Briones discusses her research on the effects and potential therapeutic targets of excessive inflammation and vascular damage in hypertension.
#ExpertAnswers: Licy Yanes Cardozo on Androgens in Cardiovascular Physiology
Licy Yanes Cardozo expands on her research exploring the role of androgens on cardiovascular physiology in cis and transgender patients.
Industry Insights with Crown Bioscience: In Vitro Technologies for Studying the Cancer-Immunity Cycle
Rajendra Kumari and Gera Goverse from Crown Bioscience provide an overview of the cancer-immunity cycle and describe in vivo, in vitro, and ex vivo research tools to study immuno-oncology.
Industry Insights with Chris Rand from Aurora Scientific
Chris Rand delves into the start and evolution of Aurora Scientific, and their journey within the preclinical research world.
#ExpertAnswers: Aaron Phillips on Neural Hemodynamic Control
Aaron Phillips discusses questions from a recent webinar on his research involving neural hemodynamic control in pre-clinical and clinical models.
#ExpertAnswers: Matthew Sparks on Vascular-Tubular Crosstalk
Matthew Sparks discusses his latest findings on a system of vascular-epithelial in the kidney that regulates pressure natriuresis.
