ALS Archives

Using ALS Patient-Derived Motor Neurons to Study TDP-43 Mislocalization

Sydney Otomancek2026-02-10T12:19:13-05:00Cell & Molecular Biology, Clinical Research, Drug Discovery & Development, Neuroscience|

In this webinar, Vera Evanson, PhD presents how iPSC-derived ALS models reproduce hallmark disease phenotypes and their use in evaluating drug responses.

Locomotor Activity: refinement, reduction and replicability ‘round the clock in animal studies

A growing body of evidence suggests that Home Cage Monitoring studies are becoming key tools for in vivo animal research for three main reasons: reduction in animal distress thereby increasing welfare, minimization of biases (wanted and unwanted), and increased reproducibility of data.