Myeloid Cells and Cardiovascular Health
Dr. Matthias Nahrendorf discusses current concepts of cell supply by the hematopoietic system, highlights open questions, and describes imaging tools for studying monocytes, macrophages and their progenitors.
Immunophysiological Mechanisms that Limit Dissemination of Microbial Signals from the Intestine
Join Dr. Gwendalyn Randolph as she discusses strategies that the intestine uses to limit the dissemination of inflammatory signals in the venous and lymphatic vasculature.
Premature Vascular Disease in Autoimmunity
Dr. Mariana Kaplan highlights the role of systemic autoimmunity in the development of vasculopathy and atherosclerosis and discusses potential strategies to prevent these complications.
Conversations Between Mucosal Immunity and the Gut Barrier
Dr. Jerrold Turner discusses the barrier function of the intestine, how the permeability of tight junctions in the gut epithelium is modulated, and the impact of this modulation on homeostasis and health.
Engineered T Cells for Cancer
Dr. Marcela Maus discusses CAR T Cell research, the components and technologies used in making a T cell product, important considerations for efficacy, and underlying mechanisms of toxicity and resistance.
Cardiovascular Disease Associated with SARS-CoV-2 and HIV Infections
Dr. Xuebin Qin discusses the development and characterization of new models of SARS-CoV-2 and HIV, and how his lab uses these models to study cardiovascular injury associated with infection.
Cellular Mechanisms Behind Alcohol Abuse and Binge Drinking Behavior
Dr. Gilles Martin discusses the cellular basis and reward pathways behind binge drinking behavior and alcohol abuse in rodent models.
Self Head Fixation Training for the Study of Perceptual Decisions in Mice
In this webinar, Andrea Benucci, PhD discusses a setup developed in his laboratory for high-throughput behavioral training of mice based on voluntary head fixation.
Sex, Drugs, and Bad Choices: Modeling Human Decision Making in Rats
Join Dr. Barry Setlow as he discusses the behavioral and biological mechanisms of cost-benefit decision making in rodent models, with a focus on how substance use can affect variability and long-term consequences in decision making.
Improving Animal Model Translation, Welfare, and Operational Efficiency with Appropriate Housing and Infrastructure Design
In this webinar, John Hasenau, DVM and Jeffrey Zynda discuss practical options for housing and infrastructural design to sustainably improve animal welfare, data reporting and reproducibility.
From “Artificial” to “Real”: What 24/7 Home Cage Monitoring Teaches Us In Pre-Clinical Neurodegenerative Disease Models
Experts discuss an innovative and scalable home cage monitoring solution called Digital Ventilated Cage (DVC), showing how it can be used to study neurodegenerative diseases and monitor biorhythmicity of small rodents.
Experimental Muscle Mechanics in Aging and Disease
Join Dr. Rizwan Qaisar and Matt Borkowski for a deep dive into the experimental protocols used for measuring muscle function and mechanics for in vivo and in vitro research.
Aging and Bone Health
In this webinar, Dr. Joy Wu will review the pathophysiology of bone loss with aging, in particular the imbalance between bone formation by osteoblasts and bone resorption by osteoclasts. She will discuss stem cell sources of osteoblasts, anabolic signaling pathways, and targeting inflammation and senescence.
Cardiac Inflammation and Repair Following Myocardial Infarction
Dr. Merry Lindsey discusses her extracellular matrix research to provide insight into future directions that will drive the understanding of recovery after myocardial infarction.
The Challenges of Sarcopenia: Definition, Underlying Mechanisms, Interventions, and Outcomes
Dr. Charlotte Peterson and Dr. Jack Guralnik will discuss the challenges of sarcopenia. They will define the disease and provide an in depth overview of the underlying mechanisms of pathology. They will then share some potential therapeutic interventions and disease outcomes for patients.
Aging and Skeletal Muscle Plasticity
Join Sue Bodine, PhD for a deep dive into her research focused on the decline in muscle mass with aging and the role that innervation plays in muscle atrophy.
Malignant Brain Aging: The Formidable Link to Neurodegeneration
Dr. De La Monte discusses her research involving the roles of brain insulin deficiency and insulin resistance in Alzheimer's disease.
Targeting Biological Aging: A New Paradigm for 21st Century Medicine
During this webinar, Dr. Matt Kaeberlein provides an overview of translational geroscience, which he believes will become the paradigm for the practice of medicine in the 21st century. He also discusses his recent work with one such intervention, the drug rapamycin, and its potential to enhance healthspan in companion dogs and people.
Rodent Models of Pharmacotherapy and Chronotherapy for Obesity and Cardiometabolic Disease
Join Christopher Axelrod and Sander Kooijman, PhD for a discussion on their research into combatting obesity using various new therapies.
Functional Ultrasound Imaging in Pain and Pharmacology Research
Dr. Sophie Pezet and Dr. Benjamin Vidal discuss methodology, applications and new possibilities enabled by functional ultrasound (fUS) imaging, with a focus on chronic pain and neuropharmacology research.
CRISPR-Enhanced Adipocyte Browning: A Cell Therapy Approach to Treat Metabolic Disease
Michael Czech, PhD discusses adipose tissue "browning" as a treatment for metabolic disease, and presents recent data using light sheet microscopy to visualize functional changes in adipose tissue depots.
Optogenetic Activation of Selective Cardiac Autonomic Neurons
In this webinar, Dr. Angel Moreno discusses how optogenetics can be used to modulate the cardiac autonomic system, with a special emphasis on experimental preparation, troubleshooting and data analysis and interpretation.
Fishing for Insights from Single-Lead and Multi-Lead ECG of Live Adult Zebrafish
In this webinar, Dr. Thao Nguyen discusses the exciting discoveries that her research team has made, debunks some common myths, and shares best-practices for data acquisition, analysis, and interpretation. Her in vivo studies of adult zebrafish cardiac electrophysiology rely on single-lead and multi-lead surface ECG in live anesthetized adult zebrafish.
Restoring Vision – Optogenetic Gene Therapy Targeted at Human ON-Bipolar Cells
Dr. Hulliger discusses his work with a new promoter that is raising hopes of improving the quality of life for people suffering from blindness.
Using EEG to Evaluate the Behavioral Effects of Benzodiazepines in Rhesus Monkeys
Lais Berro, PhD presents recent research demonstrating the anxiolytic, sedative and abuse-related effects of benzodiazepine drugs, and how they correlate with telemetry-based EEG recordings in a translational non-human primate model.
