Antibody Discovery by Single B Cell Screening on Beacon®
Amy Sheng, PhD provides an overview of antibody screening platforms and presents applications and case studies using the Beacon® platform for antibody screening.
Vascular-Tubular Crosstalk in the Renin-Angiotensin System
Matthew Sparks, MD, answers questions from a recent webinar on vascular-tubular crosstalk in the renin-angiotensin system.
#ExpertAnswers: Matthew Sparks on Vascular-Tubular Crosstalk
Matthew Sparks discusses his latest findings on a system of vascular-epithelial in the kidney that regulates pressure natriuresis.
Industry Insights with Amy Sheng on Nanobodies: An Important Tool for the Next Generation of Tumor Diagnostics and Therapeutics
Amy Sheng shares how nanobodies are emerging as important tools for tumor diagnosis and treatment.
Skin-on-Chip for Preclinical Herpes Disease Modeling
Organs-on-a-chip are attractive alternatives for bridging the translational gap between preclinical and clinical stages in vaccine development, particularly for herpes simplex virus (HSV). In this blog post, we review an article from Nature Communications on a skin-on-chip device for modeling HSV infection, as well as evaluating immune responses and antiviral drug efficacy (featured image © 2022 Sun et al., licensed under CC BY 4.0).
Creating Better Gene-Edited Cell Lines with the FAST-HDR System
Dr. Oscar Perez and Dr. Jon Weidanz discuss the basis of the FAST-HDR gene-editing system and present case studies highlighting several applications.
Talking Real Science with Chris Perry
Chris Perry shares his career path and recent project of creating a CRO to bring more opportunity to deliver solutions for muscle disorders while still benefiting his trainees.
Talking Real Science with Brent Sinclair
Brent Sinclair spends quite a bit of time outside of his research and teaching responsibilities to organize career events for graduate students in the Biology department, and he shares why these opportunities are so important for students as they get close to graduation.
Cardiometabolic Disease Pathophysiology & Novel Therapies for Atherosclerosis & Calcification
In this webinar, Dr. Michael Sturek reviews features of macrovascular atherosclerosis and microvascular dysfunction that underly ischemic events and the need for appropriate animal models for optimal translation.
Extracellular Vesicles as Breast Cancer Biomarkers
Triple-negative breast cancer is particularly aggressive, challenging to treat, and accounts for 15-20% of all breast cancers. In this blog, we review a study published in Nature Communications that examines the transforming growth factor-β targetable signaling pathway, its role in malignant cancer progression and immune suppression, and tumor-derived extracellular vesicles as diagnostic and prognostic biomarkers.
#ExpertAnswers: Bonnie Lun on Single-Domain Antibodies for Research
Dr. Bonnie Lun from Fortis Life Sciences discusses applications and advantages of using nanobodies for diagnostic and therapeutic research, and highlights Fortis/Abcore's single-domain antibody discovery services.
Intestinal Toxicity Assessment with Patient-Derived Organoids
Dr. Martin Stahl describes the use of patient-derived intestinal organoids to assess the toxicity of potential therapeutic compounds and study barrier function in a human-specific model system.
Single-Domain Antibodies: A Promising New Tool for Diagnostic and Therapeutic Research
Dr. Bonnie Lun answers questions about the applications and advantages of using nanobodies for diagnostic and therapeutic research.
Cardiac Tissue Slices: Preparation, Data Acquisition, and Analysis
Dr. Bradley Palmer demonstrates the challenging preparation of cardiac tissue slices and measurement of force and calcium.
#ExpertAnswers: Peter Ansell and Marian Navratil on Gene Expression Profiling
Peter Ansell and Dr. Marian Navratil discuss the use of novel RNA-based gene expression profiling technologies for clinical and preclinical oncology research.
Vascular-Tubular Crosstalk in the Renin-Angiotensin System
Matthew Sparks, MD, explores the vascular-tubular crosstalk in the renin-angiotensin system that may play a key role in the regulation of pressure natriuresis.
Investigating a Novel Regulator of Atrial Contractility
Dr. David Barefield gives an in-depth discussion on his research investigating the role of the MyBP-HL protein in atrial contractility.
Cell Painting: The Colorful Future of Drug Discovery
A panel Q&A originally published on Scientist.com that introduces cell painting and highlights its value in preclinical and early drug discovery programs.
Single-Domain Antibodies: A Promising New Tool for Diagnostic and Therapeutic Research
Dr. Bonnie Lun discusses applications and advantages of using single-domain antibodies for diagnostic and therapeutic research.
A Novel, All-Human Hepatic Triculture System
Join Edward LeCluyse and Paul Gallant as they discuss LifeNet Health LifeSciences' novel, all-human hepatic triculture system and discuss how it addresses the need for a convenient and human-relevant long-term hepatic culture.
#ExpertAnswers: Edward LeCluyse and Paul Gallant on a Novel Hepatic Triculture System
Edward LeCluyse and Paul Gallant discuss their novel all-human hepatic triculture system including its benefits and applications.
A Novel 3D High Throughput Co-culture System for Multiple Myeloma
During this webinar, Johannes Waldschmidt, MD, and Andreas Thomsen, MD, of the University of Freiburg in Germany, will discuss a 3D co-culture platform for the propagation of primary multiple myeloma cells ex vivo.
Industry Insights with Yuning Chen on Recombinant Proteins
Yuning Chen discusses The “ProVir™” collection and the role of recombinant virus proteins in the development of infectious disease treatment regimes and vaccines.
Integration of the HTG Transcriptome Panel into Preclinical and Clinical Programs to Drive Precision Medicine Research
Dr. Peter Ansell discusses the use of novel RNA-based gene expression profiling methods for clinical and preclinical oncology research.
#ExpertAnswers: Marta Walasek and Danielle Nguyen Truong on Stem Cells
Marta Walasek and Danielle Nguyen Truong provide tips and tricks to lock down effective genome editing conditions for CD34+ cells, methods to evaluate genome editing efficiency, and optimal culture conditions to maintain Hematopoeitic stem cell function and long-term editing effects.
