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The Cancer-Immunity Cycle: Research Solutions for Preclinical Immuno-Oncology
Cancer immunotherapy has undoubtedly expanded the cancer treatment landscape and improved patient outlook, which can in part be attributed to the recognition of the importance of the cancer-immunity cycle as a whole. In this blog, we provide an overview of the cancer-immunity cycle and highlight some preclinical models that can facilitate cancer immunotherapy research.
Passive Avoidance Response in Rats: Effects of Handling and Novel Object Recognition
Storing aversive memories is important to survival, but learned avoidance responses decrease over time without reinforcement. Since little is known about the mechanisms behind this process, Bengoetxea de Tena et al. evaluated how naive rats respond to a learning and memory task under fear conditions in a recently published study, which we review in this blog post.
Video Game Therapy: A “Game Changer” for Post-COVID Brain Fog
Originally posted on Scientist.com, this article takes a look at post-COVID brain fog, its causes, and video game therapy as a potential treatment.
Talking Real Science with Tim Hacker
This episode of Share Science features Tim Hacker, PhD, director of the Cardiovascular Physiology and Surgery core facility at the University of Wisconsin-Madison. Tim shares his career path and insights for young scientists on what it's like to run a core lab at an academic institution.
Long-Term Cardiovascular Symptoms of Mild COVID-19
Although the SARS-CoV-2 pandemic has been ongoing for more than two years, a clear understanding of the symptoms of long COVID remains elusive. In this blog post, we review a recent study published in Nature Medicine that investigated cardiovascular symptoms in individuals with prior mild SARS-CoV-2 infections.
Skin-on-Chip for Preclinical Herpes Disease Modeling
Organs-on-a-chip are attractive alternatives for bridging the translational gap between preclinical and clinical stages in vaccine development, particularly for herpes simplex virus (HSV). In this blog post, we review an article from Nature Communications on a skin-on-chip device for modeling HSV infection, as well as evaluating immune responses and antiviral drug efficacy (featured image © 2022 Sun et al., licensed under CC BY 4.0).
USDA Under Fire for Relaxing Animal Welfare Inspection Standards
Originally posted on Scientist.com, this article references a lawsuit filed by the Harvard Law School Animal Law and Policy Clinic against the United States Department of Agriculture for failing to conduct full annual inspections and highlights the need for an independent, transparent assessment program.
Biomarker Imaging for Preclinical Cancer Research
Cancer biomarkers that do not cross the translational gap to clinical practice can still further research and drug discovery. In this article, we review several techniques commonly used for cancer biomarker imaging at preclinical stages, as well as recent technological advances.
Talking Real Science with Gwen Randolph
This episode of Share Science features Gwen Randolph, PhD, a pathology and immunology professor at Washington University School of Medicine in St. Louis! Gwen shares some of her scientific passions, as well as personal experiences as a woman in science.
Overcoming Critical Issues in Glioblastoma Multiforme (GBM) Therapeutic Development
This article, originally published on Scientist.com, reviews the current standard of care for glioblastoma multiforme (GBM), challenges in developing accurate preclinical GBM models and effective therapies, and the future of GBM drug discovery.
Functional Ultrasound: Pushing the Boundaries of Neuroimaging
Although ultrasound has been used clinically for decades, advances in its temporal and spatial resolution have opened the door for its use in neuroscience research. In this blog post, we review a very recent and outstanding example of functional ultrasound neuroimaging published in Nature Methods in 2022 (featured image © 2022 Renaudin et al., licensed under CC BY 4.0).
5 Hot Topics in Refinement of Nonhuman Primate Neuroscience Research
Adapted from an article published in Laboratory Animal Science Professional Magazine, this blog entry highlights the importance of nonhuman primates (NHPs) in neuroscience research as well as five recent evidence-based NHP refinement advances in neuroscience.
Extracellular Vesicles as Breast Cancer Biomarkers
Triple-negative breast cancer is particularly aggressive, challenging to treat, and accounts for 15-20% of all breast cancers. In this blog, we review a study published in Nature Communications that examines the transforming growth factor-β targetable signaling pathway, its role in malignant cancer progression and immune suppression, and tumor-derived extracellular vesicles as diagnostic and prognostic biomarkers.
Industry Insights with Yuning Chen on Recombinant Proteins
This episode of Share Science features Yuning Chen from Sino Biological, who provides insights into their extensive library of recombinant virus proteins, as well as the importance and value of these high quality reagents!
Talking Real Science with Wendy Riggs
This episode of Share Science features Wendy Riggs, MS, an associate professor of biology at the College of the Redwoods in California. In an earlier webinar, Wendy shared how to adapt classrooms into an online environment, which she dives deeper into in this interview.
